Issue 40, 2015

Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment

Abstract

Current cell sheet-based blood vessels lack biomimetic structure and require excessively long culture times that may compromise smooth muscle cell phenotype. We modified a commercially available product for uniaxial cell sheet conditioning with thermoresponsive copolymers. Thus, culture of detachable conditioned cell sheets is shortened while retaining structural integrity and contractility.

Graphical abstract: Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment

Supplementary files

Article information

Article type
Communication
Submitted
17 jun. 2015
Accepted
17 ago. 2015
First published
19 ago. 2015

J. Mater. Chem. B, 2015,3, 7899-7902

Author version available

Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment

E. L. Lee, H. H. Bendre, A. Kalmykov and J. Y. Wong, J. Mater. Chem. B, 2015, 3, 7899 DOI: 10.1039/C5TB01171J

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