Issue 9, 2024

Fluorescent covalent organic frameworks – promising bioimaging materials

Abstract

Fluorescent covalent organic frameworks (COFs) have emerged as promising candidates for imaging living cells due to their unique properties and adjustable fluorescence. In this mini-review, we provide an overview of recent advancements in fluorescent COFs for bioimaging applications. We discuss the strategies used to design COFs with desirable properties such as high photostability, excellent biocompatibility, and pH sensitivity. Additionally, we explore the various ways in which fluorescent COFs are utilized in bioimaging, including cellular imaging, targeting specific organelles, and tracking biomolecules. We delve into their applications in sensing intracellular pH, reactive oxygen species (ROS), and specific biomarkers. Furthermore, we examine how functionalization techniques enhance the targeting and imaging capabilities of fluorescent COFs. Finally, we discuss the challenges and prospects in the field of fluorescent COFs for bioimaging in living cells, urging further research in this exciting area.

Graphical abstract: Fluorescent covalent organic frameworks – promising bioimaging materials

Article information

Article type
Review Article
Submitted
15 oct. 2023
Accepted
08 feb. 2024
First published
04 mar. 2024
This article is Open Access
Creative Commons BY-NC license

Mater. Horiz., 2024,11, 2077-2094

Fluorescent covalent organic frameworks – promising bioimaging materials

C. S. Karthik, T. Skorjanc and D. Shetty, Mater. Horiz., 2024, 11, 2077 DOI: 10.1039/D3MH01698F

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