Issue 43, 2023

Strategies for chiral separation: from racemate to enantiomer

Abstract

Chiral separation has become a crucial topic for effectively utilizing superfluous racemates synthesized by chemical means and satisfying the growing requirements for producing enantiopure chiral compounds. However, the remarkably close physical and chemical properties of enantiomers present significant obstacles, making it necessary to develop novel enantioseparation methods. This review comprehensively summaries the latest developments in the main enantioseparation methods, including preparative-scale chromatography, enantioselective liquid–liquid extraction, crystallization-based methods for chiral separation, deracemization process coupling racemization and crystallization, porous material method and membrane resolution method, focusing on significant cases involving crystallization, deracemization and membranes. Notably, potential trends and future directions are suggested based on the state-of-art “coupling” strategy, which may greatly reinvigorate the existing individual methods and facilitate the emergence of cross-cutting ideas among researchers from different enantioseparation domains.

Graphical abstract: Strategies for chiral separation: from racemate to enantiomer

Article information

Article type
Review Article
Submitted
29 mar. 2023
Accepted
26 sep. 2023
First published
27 sep. 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 11955-12003

Strategies for chiral separation: from racemate to enantiomer

J. Sui, N. Wang, J. Wang, X. Huang, T. Wang, L. Zhou and H. Hao, Chem. Sci., 2023, 14, 11955 DOI: 10.1039/D3SC01630G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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