Issue 36, 2023

Magnetic PiezoBOTs: a microrobotic approach for targeted amyloid protein dissociation

Abstract

Piezoelectric nanomaterials have become increasingly popular in the field of biomedical applications due to their high biocompatibility and ultrasound-mediated piezocatalytic properties. In addition, the ability of these nanomaterials to disaggregate amyloid proteins, which are responsible for a range of diseases resulting from the accumulation of these proteins in body tissues and organs, has recently gained considerable attention. However, the use of nanoparticles in biomedicine poses significant challenges, including targeting and uncontrolled aggregation. To address these limitations, our study proposes to load these functional nanomaterials on a multifunctional mobile microrobot (PiezoBOT). This microrobot is designed by coating magnetic and piezoelectric barium titanate nanoparticles on helical biotemplates, allowing for the combination of magnetic navigation and ultrasound-mediated piezoelectric effects to target amyloid disaggregation. Our findings demonstrate that acoustically actuated PiezoBOTs can effectively reduce the size of aggregated amyloid proteins by over 80% in less than 10 minutes by shortening and dissociating constituent amyloid fibrils. Moreover, the PiezoBOTs can be easily magnetically manipulated to actuate the piezocatalytic nanoparticles to specific amyloidosis-affected tissues or organs, minimizing side effects. These biocompatible PiezoBOTs offer a promising non-invasive therapeutic approach for amyloidosis diseases by targeting and breaking down protein aggregates at specific organ or tissue sites.

Graphical abstract: Magnetic PiezoBOTs: a microrobotic approach for targeted amyloid protein dissociation

Supplementary files

Article information

Article type
Paper
Submitted
25 may. 2023
Accepted
17 ago. 2023
First published
18 ago. 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2023,15, 14800-14808

Magnetic PiezoBOTs: a microrobotic approach for targeted amyloid protein dissociation

S. Ning, R. Sanchis-Gual, C. Franco, P. D. Wendel-Garcia, H. Ye, A. Veciana, Q. Tang, S. Sevim, L. Hertle, J. Llacer-Wintle, X. Qin, C. Zhu, J. Cai, X. Chen, B. J. Nelson, J. Puigmartí-Luis and S. Pané, Nanoscale, 2023, 15, 14800 DOI: 10.1039/D3NR02418K

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