Issue 89, 2022

A phosphine-based redox method for direct conjugation of disulfides

Abstract

Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols. We describe herein Redox-assisted Disulfide Direct Conjugation (RDDC) as a new method to enable disulfide rebridging without cross-reacting with free thiols.

Graphical abstract: A phosphine-based redox method for direct conjugation of disulfides

Supplementary files

Article information

Article type
Communication
Submitted
08 sep. 2022
Accepted
17 oct. 2022
First published
17 oct. 2022

Chem. Commun., 2022,58, 12439-12442

A phosphine-based redox method for direct conjugation of disulfides

Y. Lu, L. You and C. Chen, Chem. Commun., 2022, 58, 12439 DOI: 10.1039/D2CC04967H

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