Issue 81, 2022

Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Abstract

We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

Graphical abstract: Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Supplementary files

Article information

Article type
Communication
Submitted
23 jul. 2022
Accepted
07 sep. 2022
First published
09 sep. 2022

Chem. Commun., 2022,58, 11438-11441

Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

X. Liu, S. Zeng, M. Zhang, M. Jiang, Y. S. Kafuti, P. Shangguan, Y. Yu, Q. Chen, J. Wang, X. Peng, J. Yoon and H. Li, Chem. Commun., 2022, 58, 11438 DOI: 10.1039/D2CC04112J

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