Issue 78, 2022

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Abstract

A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

Graphical abstract: SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Supplementary files

Article information

Article type
Communication
Submitted
07 jul. 2022
Accepted
01 sep. 2022
First published
09 sep. 2022

Chem. Commun., 2022,58, 10941-10944

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Y. K. Park, P. Jangili, S. Zi, R. H. Kang, D. Kim and J. S. Kim, Chem. Commun., 2022, 58, 10941 DOI: 10.1039/D2CC03777G

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