Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications†
Lili
Huang, 
a
Peter Kam-Keung
Leung,
ab
Lawrence Cho-Cheung
Lee,
ac
Guang-Xi
Xu,
a
Yun-Wah
Lam
*a
and
Kenneth Kam-Wing
Lo
*ab
a
Peter Kam-Keung
Leung,
ab
Lawrence Cho-Cheung
Lee,
ac
Guang-Xi
Xu,
a
Yun-Wah
Lam
*a
and
Kenneth Kam-Wing
Lo
*ab
Abstract
We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.
- This article is part of the themed collection: Celebrating 10 years of ChemComm Emerging Investigators
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