Issue 4, 2021

Activatable supramolecular photosensitizers: advanced design strategies

Abstract

Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.

Graphical abstract: Activatable supramolecular photosensitizers: advanced design strategies

Article information

Article type
Review Article
Submitted
15 oct. 2020
Accepted
26 nov. 2020
First published
27 nov. 2020

Mater. Chem. Front., 2021,5, 1683-1693

Activatable supramolecular photosensitizers: advanced design strategies

M. Yang, X. Li and J. Yoon, Mater. Chem. Front., 2021, 5, 1683 DOI: 10.1039/D0QM00827C

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