Issue 45, 2021

Automated glycan assembly of peptidoglycan backbone fragments

Abstract

We report the automated glycan assembly (AGA) of different oligosaccharide fragments of the bacterial peptidoglycan (PGN) backbone. Iterative addition on a solid support of an acetyl glucosamine and a new muramic acid building block is followed by cleavage from the solid support and final deprotection providing 10 oligosaccharides up to six units.

Graphical abstract: Automated glycan assembly of peptidoglycan backbone fragments

Supplementary files

Article information

Article type
Communication
Submitted
10 oct. 2021
Accepted
22 oct. 2021
First published
25 oct. 2021
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2021,19, 9829-9832

Automated glycan assembly of peptidoglycan backbone fragments

P. Dallabernardina, V. Benazzi, J. D. Laman, P. H. Seeberger and F. F. Loeffler, Org. Biomol. Chem., 2021, 19, 9829 DOI: 10.1039/D1OB01987B

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