Computational study on N-triflylphosphoramide-catalyzed enantioselective hydroamination of alkenyl thiourea

Abstract

The mechanism of the enantioselective intramolecular hydroamination of alkenyl thiourea catalyzed by chiral binaphthol N-triflylphosphoramide (NPTA) was investigated using density functional theory calculations. This study reveals the details of the hydrogen bonding mode between NPTA and the substrate and indicates the importance of the dual hydrogen binding properties of the thiourea moiety for the reactivity and stereoselectivity of the hydroamination.