Issue 100, 2021

The modern role of boron as a ‘magic element’ in biomedical science: chemistry perspective

Abstract

Boron was misconstrued as a toxic element for animals, which retarded the growth of boron-containing drug discovery in the last century. Nevertheless, modern applications of boronic acid derivatives are attractive in biomedical applications after the declaration that boron is a ‘probable essential element’ for humans by the WHO. Additionally, the approval of five boronic acid-containing drugs by the FDA has vastly impacted the use of boron in medicinal chemistry, chemical biology, drug delivery, biomaterial exploration, pharmacological improvements, and nutrition. This review article focuses on the chemistries attributed to boronic acids at physiological pH, enticing chemists to multidisciplinary applications. Prospective uses of boronic acid in pharma and chemical biology, along with prospects and challenges, are also part of the deliberation. Understanding these fundamental chemistries and interactions of boronic acid in biological systems will enable solving future challenges in drug discovery and executing space-age applications.

Graphical abstract: The modern role of boron as a ‘magic element’ in biomedical science: chemistry perspective

Article information

Article type
Highlight
Submitted
29 sep. 2021
Accepted
16 nov. 2021
First published
17 nov. 2021

Chem. Commun., 2021,57, 13629-13640

The modern role of boron as a ‘magic element’ in biomedical science: chemistry perspective

S. Chatterjee, N. M. Tripathi and A. Bandyopadhyay, Chem. Commun., 2021, 57, 13629 DOI: 10.1039/D1CC05481C

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