Issue 48, 2020

Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases

Abstract

Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases. Celastrol, a compound isolated from a Chinese medicinal herb, holds great potential in treating multiple inflammation-associated diseases. However, its further clinical use is limited by its poor solubility, bioavailability, and high organ toxicity. With the advancement of nanotechnology, the nano-delivery of celastrol can effectively improve its oral bioavailability, maximize its efficacy and minimize its side effects. Here, we summarize the roles of celastrol in the treatment of various inflammation-associated diseases, with a special emphasis on its role in modulating immune cell signaling or non-immune cell signaling within the inflammatory microenvironment, and we highlight the latest advances in nano-delivery strategies for celastrol to treat diseases associated with inflammation.

Graphical abstract: Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases

Article information

Article type
Review Article
Submitted
11 ago. 2020
Accepted
13 oct. 2020
First published
15 oct. 2020

J. Mater. Chem. B, 2020,8, 10954-10965

Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases

G. Fang and B. Tang, J. Mater. Chem. B, 2020, 8, 10954 DOI: 10.1039/D0TB01939A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements