Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

Abstract

MRI with hyperpolarized ¹²⁹Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as a ¹²⁹Xe MRI contrast agent with a moderate exchange rate, sufficient stability and feasible surface modification. The α_vβ₃ integrin overexpressed by non-small-cell lung cancer A549 cells was successfully detected by ¹²⁹Xe MRI with high specificity through adequate surface modifications.