A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Iaroslav Baglai; Michel Leeman; Richard M. Kellogg; Willem L. Noorduin

doi:10.1039/C8OB02660B

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A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam†

Iaroslav Baglai,^a Michel Leeman,^b Richard M. Kellogg^b and Willem L. Noorduin

*^a

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* Corresponding authors

^a AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands
E-mail: noorduin@amolf.nl

^b Syncom BV, Kadijk 3, 9747 AT Groningen, The Netherlands

Abstract

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

This article is part of the themed collection: Mechanistic, computational & physical organic chemistry in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB02660B
Article type: Communication
Submitted: 26 oct. 2018
Accepted: 05 nov. 2018
First published: 05 nov. 2018

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Org. Biomol. Chem., 2019,17, 35-38

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A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

I. Baglai, M. Leeman, R. M. Kellogg and W. L. Noorduin, Org. Biomol. Chem., 2019, 17, 35 DOI: 10.1039/C8OB02660B

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Organic & Biomolecular Chemistry

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam†

Abstract

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A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

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