Issue 1, 2018

A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

Abstract

A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding subjects in organic synthetic chemistry. This minireview focuses on recent advances in site-selective C–H functionalization on 2-pyridone. The reported procedures are categorized according to the site selectivity that is achieved, and the substrate scope, limitations, mechanism, and controlling factors are briefly summarized.

Graphical abstract: A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

Article information

Article type
Minireview
Submitted
18 oct. 2017
Accepted
26 nov. 2017
First published
27 nov. 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 22-32

A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

K. Hirano and M. Miura, Chem. Sci., 2018, 9, 22 DOI: 10.1039/C7SC04509C

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