Issue 9, 2016

Triamcinolone–carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts

Abstract

Repetitive intra-articular corticosteroid injections are inevitable for treating synovial inflammation in advanced arthritis. However, short- and long-term use of corticosteroids usually triggers serious side effects (i.e., adrenal insufficiency, hyperglycemia, Cushing syndrome, osteoporosis, Charcot arthropathy, etc.). This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-α, IL-1β, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Specifically, conjugation of triamcinolone and multi-walled carbon nanotubes inactivated nuclear factor-κB via inhibition of the phosphorylation of mitogen-activated protein kinases and the serine/threonine kinase Akt. In summary, low-dose triamcinolone conjugation with carbon nanotubes significantly inhibited the inflammatory response of fibroblast-like synoviocytes by achieving highly efficient intracellular trafficking and suggested a potential drug candidate for resolving side effects associated with conventional arthritis treatment.

Graphical abstract: Triamcinolone–carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts

Supplementary files

Article information

Article type
Paper
Submitted
18 ago. 2015
Accepted
12 oct. 2015
First published
12 oct. 2015

J. Mater. Chem. B, 2016,4, 1660-1671

Triamcinolone–carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts

Y. K. Lee, J. K. Choi, Y. J. Kang, H. W. Kim, S. Kim, C. Park, D. Khang and S. Kim, J. Mater. Chem. B, 2016, 4, 1660 DOI: 10.1039/C5TB01693B

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