Issue 4, 2016

Ruthenium-catalyzed selective imine synthesis from nitriles and secondary alcohols under hydrogen acceptor- and base-free conditions

Abstract

We report a method for the selective synthesis of imines from nitriles and secondary alcohols using a hydrogen-transfer strategy. The imine bond is efficiently formed between the nitrogen atom of nitrile and the α-carbon of secondary alcohol, catalyzed by a ruthenium dihydride complex with pyridine as a stabilizing ligand.

Graphical abstract: Ruthenium-catalyzed selective imine synthesis from nitriles and secondary alcohols under hydrogen acceptor- and base-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
18 nov. 2015
Accepted
01 feb. 2016
First published
11 feb. 2016

Org. Chem. Front., 2016,3, 475-479

Ruthenium-catalyzed selective imine synthesis from nitriles and secondary alcohols under hydrogen acceptor- and base-free conditions

D. Kim, B. Kang and S. H. Hong, Org. Chem. Front., 2016, 3, 475 DOI: 10.1039/C5QO00378D

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