Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

Andrew I. Share; Khushali Patel; Cristina Nativi; Eun J. Cho; Oscar Francesconi; Nathalie Busschaert; Philip A. Gale; Stefano Roelens; Jonathan L. Sessler

doi:10.1039/C6CC03645G

Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro†

Andrew I. Share,^a Khushali Patel,^a Cristina Nativi,^b Eun J. Cho,^c Oscar Francesconi,*^b Nathalie Busschaert,‡^d Philip A. Gale,

*^d Stefano Roelens*^b and Jonathan L. Sessler*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, The University of Texas, Austin, TX 78712-1224, USA
E-mail: sessler@cm.utexas.edu

^b Department of Chemistry and INSTM, University of Florence, Polo Scientifco e Tecnologico, 50019 Sesto Fiorentino, Firenze, Italy
E-mail: oscar.francesconi@unifi.it, stefano.roelens@unifi.it

^c Targeted Therapeutic Drug Discovery and Development (TTDDDP), College of Pharmacy, University of Texas-Austin, TX 78723, Austin, USA

^d Chemistry, University of Southampton, Southampton, UK
E-mail: philip.gale@soton.ac.uk

Abstract

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl⁻ transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.

This article is part of the themed collection: Host–guest chemistry

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DOI: https://doi.org/10.1039/C6CC03645G
Article type: Communication
Submitted: 02 may. 2016
Accepted: 18 may. 2016
First published: 18 may. 2016
This article is Open Access

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Chem. Commun., 2016,52, 7560-7563

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Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

A. I. Share, K. Patel, C. Nativi, E. J. Cho, O. Francesconi, N. Busschaert, P. A. Gale, S. Roelens and J. L. Sessler, Chem. Commun., 2016, 52, 7560 DOI: 10.1039/C6CC03645G

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Chemical Communications

Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro†

Abstract

Supplementary files

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Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

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