Issue 27, 2015

Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

Abstract

We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein–bisphosphonate conjugate.

Graphical abstract: Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

Supplementary files

Article information

Article type
Paper
Submitted
11 may. 2015
Accepted
07 jun. 2015
First published
09 jun. 2015
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2015,3, 5544-5552

Author version available

Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

R. V. Bell, L. A. Rochford, R. T. M. de Rosales, M. Stevens, J. V. M. Weaver and S. A. F. Bon, J. Mater. Chem. B, 2015, 3, 5544 DOI: 10.1039/C5TB00893J

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