Issue 10, 2015

Organocatalysis by p-sulfonic acid calix[4]arene: a convenient and efficient route to 2,3-dihydroquinazolin-4(1H)-ones in water

Abstract

An efficient and eco-friendly method is reported for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from the direct cyclocondensation of anthranilamide with aldehydes using p-sulfonic acid calix[4]arene (p-SAC) as a recyclable organocatalyst in excellent yields in water at room temperature. The catalyst was reusable without significant loss of catalytic efficiency. Operational simplicity, the compatibility with various functional groups, non-chromatographic purification technique, high yields and mild reaction conditions are the notable advantages of this procedure. Large scale reaction demonstrated the practical applicability of this methodology.

Graphical abstract: Organocatalysis by p-sulfonic acid calix[4]arene: a convenient and efficient route to 2,3-dihydroquinazolin-4(1H)-ones in water

Supplementary files

Article information

Article type
Paper
Submitted
20 nov. 2014
Accepted
22 dic. 2014
First published
22 dic. 2014

RSC Adv., 2015,5, 7755-7760

Author version available

Organocatalysis by p-sulfonic acid calix[4]arene: a convenient and efficient route to 2,3-dihydroquinazolin-4(1H)-ones in water

M. Rahman, I. Ling, N. Abdullah, R. Hashim and A. Hajra, RSC Adv., 2015, 5, 7755 DOI: 10.1039/C4RA16374E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements