From the journal:

Chemical Communications

Beyond Serendipity: Uncovering Novel Ratiometric Urea•24DHBA Cocrystals through Mechanochemistry and MicroED

Ankur Bonia,   Diptajyoti Gogoi,   Nabadeep Kalita,   Takanori Nakane,   Akihiro Kawamoto,   Khaled Althubeiti,   Toshiyuki Sasaki,   Genji Kurisu  and  Ranjit Thakuria  

Abstract

Mechanochemical synthesis of urea cocrystals with 2,4-dihydroxybenzoic acid (24DHBA) reveals two new stoichiometric forms: (urea)₂•(24DHBA) and (urea)₂•(24DHBA)₂, not accessible via solution methods. The known (urea)₀.₅•(24DHBA) form remains the most stable. These findings provide critical insights into stoichiometric tuning of agro-cocrystals and pave the way for their practical application in sustainable agriculture.

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Article information

DOI
https://doi.org/10.1039/D5CC03628C
Article type
Communication
Submitted
27 Jun 2025
Accepted
26 Aug 2025
First published
03 Sep 2025

Chem. Commun., 2025, Accepted Manuscript

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Beyond Serendipity: Uncovering Novel Ratiometric Urea•24DHBA Cocrystals through Mechanochemistry and MicroED

A. Bonia, D. Gogoi, N. Kalita, T. Nakane, A. Kawamoto, K. Althubeiti, T. Sasaki, G. Kurisu and R. Thakuria, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC03628C

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