Themed collection Chemical Biology of Metals

18 items
Open Access Editorial

Introduction to “Chemical biology of metals”

Angela Casini (Technical University of Munich, Germany), Hui Chao (Sun Yat-Sen University, China), Hongzhe Sun (University of Hong Kong, China), and Christopher J. Chang (University of California, Berkeley, United States) introduce the themed collection on ‘Chemical biology of metals’.

Graphical abstract: Introduction to “Chemical biology of metals”
From the themed collection: Chemical Biology of Metals
Open Access Opinion

Copper binding and protein aggregation: a journey from the brain to the human lens

Metal ions are implicated in many proteinopathies. Three case studies are discussed to address how copper binding impacts protein folding and aggregation, and its relevance in understanding the polymorphic nature of the aggregates related to disease.

Graphical abstract: Copper binding and protein aggregation: a journey from the brain to the human lens
From the themed collection: Celebrating Latin American Chemistry
Open Access Review Article

Unlocking the potential of platinum drugs: organelle-targeted small-molecule platinum complexes for improved anticancer performance

This review offers a concise overview of platinum-based anticancer complexes targeting various organelles, aiming to overcome the limitations of existing platinum drugs.

Graphical abstract: Unlocking the potential of platinum drugs: organelle-targeted small-molecule platinum complexes for improved anticancer performance
From the themed collection: Chemical Biology of Metals
Open Access Review Article

Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration

This review describes how transition metal ions induce the conformational and functional changes of neurotransmitters.

Graphical abstract: Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration
From the themed collection: Chemical Biology of Metals
Open Access Communication

Discovery of cisplatin-binding proteins by competitive cysteinome profiling

A competitive activity-based protein profiling strategy was developed to identify cisplatin-binding cysteines in MCF-7 proteomes, among which cisplatin-binding sites in GLRX1, TXNDC17 and MetAP1 were biochemically verified.

Graphical abstract: Discovery of cisplatin-binding proteins by competitive cysteinome profiling
From the themed collection: Chemical Biology of Metals
Open Access Paper

Mining proteomes for zinc finger persulfidation

A meta-analysis of 22 persulfide-specific proteomics datasets reveals widespread persulfidation of zinc finger proteins across various species, highlighting the role of persulfidation as an important post-translational modification.

Graphical abstract: Mining proteomes for zinc finger persulfidation
From the themed collection: Chemical Biology of Metals
Open Access Paper

An AIE-based monofunctional Pt(II) complex for photodynamic therapy through synergism of necroptosis–ferroptosis

We report an AIE-based monofunctional Pt(II) complex with increased singlet oxygen production and negligible dark toxicity. This enters cells via endocytosis, accumulates in lysosomes and produces ROS under light irradiation, causing FSP1-downregulation and cell death by ferroptosis and necroptosis.

Graphical abstract: An AIE-based monofunctional Pt(ii) complex for photodynamic therapy through synergism of necroptosis–ferroptosis
From the themed collection: Chemical Biology of Metals
Open Access Paper

Reduction-cleavable desferrioxamine B pulldown system enriches Ni(II)-superoxide dismutase from a Streptomyces proteome

Two resins with the hydroxamic acid siderophore desferrioxamine B (DFOB) immobilised as a free ligand or its Fe(III) complex prepared to screen the Streptomyces pilosus proteome for proteins involved in siderophore-mediated Fe(III) uptake enriched for Ni(II)-superoxide dismutase on the apo-DFOB resin.

Graphical abstract: Reduction-cleavable desferrioxamine B pulldown system enriches Ni(ii)-superoxide dismutase from a Streptomyces proteome
From the themed collection: Chemical Biology of Metals
Open Access Paper

Comparison of click-capable oxaliplatin and cisplatin derivatives to better understand Pt(II)-induced nucleolar stress

A novel click-capable oxaliplatin mimic as a tool to study Pt(II)-induced nucleolar stress.

Graphical abstract: Comparison of click-capable oxaliplatin and cisplatin derivatives to better understand Pt(ii)-induced nucleolar stress
From the themed collection: Chemical Biology of Metals
Open Access Paper

Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection

A gallium compound shows strong antibacterial effects against Pseudomonas aeruginosa while being low in cytotoxicity. It eradicates the pathogen by targeting quorum sensing and iron metabolism pathways, making it a “dual-action” antibacterial agent.

Graphical abstract: Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection
From the themed collection: Chemical Biology of Metals
Open Access Paper

Siderocalin fusion proteins enable a new 86Y/90Y theranostic approach

The mammalian protein siderocalin binds hydroxypyridinone complexes of trivalent rare-earth metals and f-elements through cation-π and electrostatic interactions. It can also be fused with biological vectors for the targeted delivery of imaging and therapeutic radionuclides.

Graphical abstract: Siderocalin fusion proteins enable a new 86Y/90Y theranostic approach
From the themed collection: Chemical Biology of Metals
Open Access Paper

The effect of metalation on antimicrobial piscidins imbedded in normal and oxidized lipid bilayers

Structural changes due to metalation of the ATCUN motif of piscidins embedded in lipid bilayers are revealed through molecular dynamics simulations.

Graphical abstract: The effect of metalation on antimicrobial piscidins imbedded in normal and oxidized lipid bilayers
From the themed collection: Chemical Biology of Metals
Open Access Paper

An anti-glioblastoma gold(I)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition

A new gold(I)-based therapeutic strategy to treat glioblastoma multiforme (GBM).

Graphical abstract: An anti-glioblastoma gold(i)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition
From the themed collection: Chemical Biology of Metals
Open Access Paper

Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo

Prostate specific antigen binding Designed Ankyrin Repeat Proteins (DARPins) were selected and C-terminally conjugated for Gallium-68 radiolabelling. Two of the developed tracers showed specific uptake in mouse prostate tumour models.

Graphical abstract: Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo
From the themed collection: Chemical Biology of Metals
Open Access Paper

Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes

This work describes successful radiochemical labeling and subsequent in vivo evaluation of radiolanthanide-tagged versions of lanmodulin (LanM), a lathanide-binding protein.

Graphical abstract: Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes
From the themed collection: Chemical Biology of Metals
Open Access Paper

A monoadduct generating Ru(II) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin

Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(II) complexes were created that act as biological mimics of phenanthriplatin with improved properties.

Graphical abstract: A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin
From the themed collection: Chemical Biology of Metals
Open Access Paper

Investigation of metal modulation of oxytocin structure receptor-mediated signaling

Oxytocin and a library of analogs show metal-dependent modulation of MAPK activation in oxytocin-receptor-expressing HEK293 cells.

Graphical abstract: Investigation of metal modulation of oxytocin structure receptor-mediated signaling
From the themed collection: Chemical Biology of Metals
Open Access Paper

Dinuclear nitrido-bridged osmium complexes inhibit the mitochondrial calcium uniporter and protect cortical neurons against lethal oxygen–glucose deprivation

We have investigated the biological properties of the osmium analogue of a potent ruthenium-based mitochondrial calcium uniporter inhibitor and have found it to possess distinct properties.

Graphical abstract: Dinuclear nitrido-bridged osmium complexes inhibit the mitochondrial calcium uniporter and protect cortical neurons against lethal oxygen–glucose deprivation
From the themed collection: Chemical Biology of Metals
18 items

About this collection

This themed collection, guest edited by Angela Casini (Technical University of Munich, Germany), Christopher J. Chang (University of California, Berkeley, United States), Hui Chao (Sun Yat-Sen University, China) and Hongzhe Sun (University of Hong Kong, China) offers articles showcasing the ongoing interest in the chemical biology of metals.

Recent years have witnessed significant advances in the development of new imaging probes that can probe the physiological and pathological roles of metals in biology and/or leverage unique properties of metal coordination chemistry and metal-based medicines. In addition, significant progress has been made in understanding metallomedicines and studying metal-based catalysis and signaling in living systems. We have collected contributions that are representative of the tremendous promise and pace of growth in this area.

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