Dual-enhanced Raman scattering sensors incorporating graphene plasmonic nanoresonators

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Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy

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Analyst, 2020, 145, 3440
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In-line whole blood fractionation for Raman analysis of blood plasma

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Analyst, 2019, 144, 602
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Novel SERS-based process analysis for label-free segmented flow screenings

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Lab Chip, 2020, 20, 2364
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NanoPADs and nanoFACEs: an optically transparent nanopaper-based device for biomedical applications

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Lab Chip, 2020, 20, 3322
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Process optimization for the synthesis of functionalized Au@AgNPs for specific detection of Hg2+ based on quality by design (QbD)

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SERS-based quantification of albuminuria in the normal-to-mildly increased range

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Analyst, 2018, 143, 5372
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Rapid detection of hypnotics using surface-enhanced Raman scattering based on gold nanoparticle co-aggregation in a wet system

Hiroki Segawa, Takao Fukuoka, Tamitake Itoh, Yuichi Imai, Yuko T. Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori and Hiroyuki Inoue

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Optical characterization of a nanogel–nanostar plasmonic nanocomposite for microfluidic sensing and surface-enhanced Raman scattering

Casey Folks, Nishka Ghiloria and Laura D. Casto-Boggess

Analyst, 2025, 150, 5043
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Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments

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Chem. Sci., 2020, 11, 4563
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Engineered nanopatterned substrates for high-sensitive localized surface plasmon resonance: an assay on biomacromolecules

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J. Mater. Chem. B, 2017, 5, 5473
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Microfluidics-aided fabrication of 3D micro-nano hierarchical SERS substrate for rapid detection of dual hepatocellular carcinoma biomarkers

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Lab Chip, 2024, 24, 528
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SERS-based droplet microfluidics for high-throughput gradient analysis

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Lab Chip, 2019, 19, 674
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Screening for urothelial carcinoma cells in urine based on digital holographic flow cytometry through machine learning and deep learning methods

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Lab Chip, 2024, 24, 2736
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SERS-active metal-dielectric nanostructures integrated in microfluidic devices for label-free quantitative detection of miRNA

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Finite-difference time-domain to screen Au NPs as SERS active substrate for the sensitive determination of prohibited drugs in fish via solvent cleaning

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Anal. Methods, 2022, 14, 921
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SERS monitoring of the Fenton degradation reaction based on microfluidic droplets and alginate microparticles

Shuai Yue, Wenqi Ye and Zhangrun Xu

Analyst, 2019, 144, 5882
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Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

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Lab Chip, 2022, 22, 665
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A LoC-SERS platform based on triple signal amplification for highly sensitive detection of colorectal cancer miRNAs

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Anal. Methods, 2023, 15, 4194
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Surface functionalized 3D printed metal structures as next generation recyclable SERS substrates

Uzma Malik, Roxanne Hubesch, Paramita Koley, Maciej Mazur, Sunil Mehla, Sai Kishore Butti, Milan Brandt, P. R. Selvakannan and Suresh Bhargava

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Quantitative surface-enhanced Raman spectroscopy chemical analysis using citrate as an in situ calibrant

Reza Salemmilani, Rustin Y. Mirsafavi, Augustus W. Fountain, Martin Moskovits and Carl D. Meinhart

Analyst, 2019, 144, 1818
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Cellular heterogeneity identified by single-cell alkaline phosphatase (ALP) via a SERRS-microfluidic droplet platform

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Lab Chip, 2019, 19, 335
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Self-assembly-based integration of Ag@Au oligomers and core/shell nanoparticles on polymer chips for efficient sensing devices

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Soft Matter, 2023, 19, 321
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Droplet control technologies for microfluidic high throughput screening (μHTS)

Muhsincan Sesen, Tuncay Alan and Adrian Neild

Lab Chip, 2017, 17, 2372
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In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

Anuradha R. Pallipurath, Pierre-Baptiste Flandrin, Lois E. Wayment, Chick C. Wilson and Karen Robertson

Mol. Syst. Des. Eng., 2020, 5, 294
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Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis

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Lab Chip, 2020, 20, 4632
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Investigation of copper oxidation states in plasmonic nanomaterials by XAS and Raman spectroscopy

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Phys. Chem. Chem. Phys., 2020, 22, 2193
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Nanostars—decorated microfluidic sensors for surface enhanced Raman scattering targeting of biomolecules

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J. Phys. Photonics, 2020, 2, 024008
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Review—Surface-Enhanced Raman Scattering Sensors for Food Safety and Environmental Monitoring

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J. Electrochem. Soc., 2018, 165, B3098
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Development of surface-enhanced Raman spectroscopy application for determination of illicit drugs: Towards a practical sensor

Borong Yu, Meihong Ge, Pan Li, Qiwen Xie and Liangbao Yang

Talanta, 2019, 191, 1
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Real-time Raman detection by the cavity mode enhanced Raman scattering

Yang Liu, Xiaorui Tian, Weiran Guo, Wenqiang Wang, Zhiqiang Guan and Hongxing Xu

Nano Res., 2019, 12, 1643
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Photonic monitoring of treatment during infection and sepsis: development of new detection strategies and potential clinical applications

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Anal Bioanal Chem, 2018, 410, 773
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Ultrasensitive and Simultaneous Detection of Two Cytokines Secreted by Single Cell in Microfluidic Droplets via Magnetic-Field Amplified SERS

Dan Sun, Fanghao Cao, Weiqing Xu, Qidan Chen, Wei Shi and Shuping Xu

Anal. Chem., 2019, 91, 2551
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Towards malaria field diagnosis based on surface-enhanced Raman scattering with on-chip sample preparation and near-analyte nanoparticle synthesis

Clement Yuen, Xiaohong Gao, James Jia Ming Yong, Prem Prakash, Chalapathy Raja Shobana, Perera Adhikarige Taniya Kaushalya, Yuemei Luo, Yanru Bai, Chun Yang, Peter R. Preiser and Quan Liu

Sensors and Actuators B: Chemical, 2021, 343, 130162
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Optimization of microfluidic functionalization of a plasmonic-based device for selective capture of anti-folic acid in solution

Federica Granata, Maria Laura Coluccio, Antonio Minopoli, Paola Cuzzola, Roberta Costa, Natalia Malara, Mario Iodice, Giuseppe Coppola and Francesco Gentile

Biosensors and Bioelectronics: X, 2022, 12, 100226
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Surface enhanced Raman spectroscopy in microchip electrophoresis

Anna Tycova, Renata F. Gerhardt and Detlev Belder

Journal of Chromatography A, 2018, 1541, 39
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Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones

Marlitt Viehrig, Anil H. Thilsted, Marco Matteucci, Kaiyu Wu, Darmin Catak, Michael S. Schmidt, Kinga Zór and Anja Boisen

ACS Appl. Mater. Interfaces, 2018, 10, 37417
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Spectroscopic molecular-fingerprint profiling of saliva

Emma Buchan, Liam Kelleher, Michael Clancy, Jonathan James Stanley Rickard and Pola Goldberg Oppenheimer

Analytica Chimica Acta, 2021, 1185, 339074
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Molecular-Imprinting-Based Surface-Enhanced Raman Scattering Sensors

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ACS Sens., 2020, 5, 601
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Analytical settings for in-flow biocatalytic reaction monitoring

Enrica Calleri, Caterina Temporini, Raffaella Colombo, Sara Tengattini, Francesca Rinaldi, Gloria Brusotti, Sandra Furlanetto and Gabriella Massolini

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Microfluidics and Surface-Enhanced Raman Spectroscopy: A Perfect Match for New Analytical Tools

Gustavo Ochoa-Vazquez, Boris Kharisov, Ana Arizmendi-Morquecho, Anais Cario, Cyril Aymonier, Samuel Marre and Israel Lopez

IEEE Trans.on Nanobioscience, 2019, 18, 558
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Raman Spectroscopic Detection in Continuous Microflow Using a Chip-Integrated Silver Electrode as an Electrically Regenerable Surface-Enhanced Raman Spectroscopy Substrate

Eva-Maria Höhn, Rajapandiyan Panneerselvam, Anish Das and Detlev Belder

Anal. Chem., 2019, 91, 9844
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Magnetic SERS Composite Nanoparticles for Microfluidic Oil Reservoir Tracer Detection and Nanoprobe Applications

Sehoon Chang, Wonjin Yun, Shannon L. Eichmann, Martin E. Poitzsch and Wei Wang

ACS Appl. Nano Mater., 2019, 2, 997
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A microfluidic device enabling surface-enhanced Raman spectroscopy at chip-integrated multifunctional nanoporous membranes

Benjamin Krafft, Rajapandiyan Panneerselvam, David Geissler and Detlev Belder

Anal Bioanal Chem, 2020, 412, 267
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Microfluidic lab-on-chip advances for liquid–liquid extraction process studies

Ange Maurice, Johannes Theisen and Jean-Christophe P. Gabriel

Current Opinion in Colloid & Interface Science, 2020, 46, 20
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From Genotype to Phenotype: Raman Spectroscopy and Machine Learning for Label-Free Single-Cell Analysis

Yirui Zhang, Kai Chang, Babatunde Ogunlade, Liam Herndon, Loza F. Tadesse, Amanda R. Kirane and Jennifer A. Dionne

ACS Nano, 2024, 18, 18101
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Preparation and application of microfluidic SERS substrate: Challenges and future perspectives

Jiuchuan Guo, Fanyu Zeng, Jinhong Guo and Xing Ma

Journal of Materials Science & Technology, 2020, 37, 96
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Mass Activated Droplet Sorting (MADS) Enables High‐Throughput Screening of Enzymatic Reactions at Nanoliter Scale

Daniel A. Holland‐Moritz, Michael K. Wismer, Benjamin F. Mann, Iman Farasat, Paul Devine, Erik D. Guetschow, Ian Mangion, Christopher J. Welch, Jeffrey C. Moore, Shuwen Sun and Robert T. Kennedy

Angewandte Chemie, 2020, 132, 4500
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SERS-activated platforms for chemical contaminants in food: Probes, encoding methods, and detection

Huanhuan Li, Suleiman A. Haruna, Wei Sheng, Qiyi Bei, Waqas Ahmad, Muhammad Zareef, Quansheng Chen and Zhen Ding

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Novel Digital SERS-Microfluidic Chip for Rapid and Accurate Quantification of Microorganisms

Ping Wen, Feng Yang, Haixia Zhao, Yi Xu, Shunbo Li and Li Chen

Anal. Chem., 2024, 96, 1454
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A review of SERS coupled microfluidic platforms: From configurations to applications

Chenyang Wang, Guojun Weng, Jianjun Li, Jian Zhu and Junwu Zhao

Analytica Chimica Acta, 2024, 1296, 342291
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Microfluidic biochip platform sensitized by AgNPs for SERS based rapid detection of uric acid

Shubham Mishra, Sanket Goel and Prabhat K Dwivedi

J. Micromech. Microeng., 2022, 32, 095007
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Chiroptical detection and mutation analysis of cancer-associated extracellular vesicles using microfluidics with oriented chiral nanoparticles

Yoon-Tae Kang, Ji-Young Kim, Emine Sumeyra Turali-Emre, Abha Kumari, Hee-Jeong Jang, Minjeong Cha, Colin Palacios-Rolston, Chitra Subramanian, Emma Purcell, Sarah Owen, Chung-Man Lim, Rishindra Reddy, Shruti Jolly, Nithya Ramnath, Sunitha Nagrath and Nicholas A. Kotov

Matter, 2024, 7, 4373
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The potential of SERS as an AST methodology in clinical settings

Ota Samek, Silvie Bernatová and Fadi Dohnal

Nanophotonics, 2021, 10, 2537
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SERS-based microfluidic sensor for sensitive detection of circulating tumor markers: A critical review

Yeru Wang, Rongke Gao, Changbiao Zhan, Huakun Jia, Xiaozhe Chen, Yang Lu, Yujie Feng and Liandong Yu

Coordination Chemistry Reviews, 2025, 523, 216289
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Microfluidic assessment of nutritional biomarkers: Concepts, approaches and advances

Shubham Nimbkar, M. Maria Leena, Jeyan Arthur Moses and Chinnaswamy Anandharamakrishnan

Critical Reviews in Food Science and Nutrition, 2024, 64, 5113
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Emerging Raman spectroscopy and saliva-based diagnostics: from challenges to applications

Emma Buchan, Mike Hardy, Paulo de Carvalho Gomes, Liam Kelleher, Hin On Martin Chu and Pola Goldberg Oppenheimer

Applied Spectroscopy Reviews, 2024, 59, 277
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Tuning plasmons of metal-coated microsphere arrays towards optimized surface-enhanced spectroscopy

Narcisa Nechita and Cosmin Farcău

Opt. Express, 2021, 29, 42238
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3D silver metallized nanotrenches fabricated by nanoimprint lithography as flexible SERS detection platform

Alia Colniță, Daniel Marconi, Nicoleta Elena Dina, Ioana Brezeștean, Diana Bogdan and Ioan Turcu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 276, 121232
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Interference-Enhanced Raman Spectroscopy as a Promising Tool for the Detection of Biomolecules on Raman-Compatible Surfaces

Susanne Pahlow, Thomas Mayerhöfer, Marie van der Loh, Uwe Hübner, Jan Dellith, Karina Weber and Jürgen Popp

Anal. Chem., 2018, 90, 9025
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The impact of LSP–SPP coupling on the electric field enhancement of a composite SERS substrate consisting of an Au 2D sinusoidal grating and Ag colloidal nanoparticles

Zhaoyi Chen, Ke Feng, Zhibin Chen, Jinxing Shen, Huanliang Li and Jialiang Dong

Optics Communications, 2022, 508, 127797
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Biosensing Using SERS Active Gold Nanostructures

Gour Mohan Das, Stefano Managò, Maria Mangini and Anna Chiara De Luca

Nanomaterials, 2021, 11, 2679
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Microfluidic surface-enhanced Raman spectroscopy aided by artificial intelligence for biosensing

Muhammad Sohail Ibrahim, Myeong-Seok Lee, Sejin Park, Abdul Naman, Dongho Lee, Yunsang Kwak and Minseok Kim

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A Critical Review on Ultrasensitive, Spectroscopic-based Methods for High-throughput Monitoring of Bacteria during Infection Treatment

Nicoleta Elena Dina, Alia Colniţă, Tiberiu Szöke-Nagy and Alin Sebastian Porav

Critical Reviews in Analytical Chemistry, 2017, 47, 499
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Recent advances in nano‐photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Timea Frosch, Andreas Knebl and Torsten Frosch

Nanophotonics, 2018, 9, 19
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Advanced Design of Microfluidic Chip Based on SPP-LSP Plasmonic Coupling for SERS Detection with High Sensitivity and Reliability

V. Burtsev, E. Miliutina, M. Erzina, Y. Kalachyova, R. Elashnikov, V. Svorcik and O. Lyutakov

J. Phys. Chem. C, 2019, 123, 30492
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In Situ Synthesis of SERS-Active Au@POM Nanostructures in a Microfluidic Device for Real-Time Detection of Water Pollutants

Marta Lafuente, Ismael Pellejero, Alberto Clemente, Miguel A. Urbiztondo, Reyes Mallada, Santiago Reinoso, María P. Pina and Luis M. Gandía

ACS Appl. Mater. Interfaces, 2020, 12, 36458
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Microfluidics for detection of exosomes and microRNAs in cancer: State of the art

Seyed Mojtaba Mousavi, Seyed Mohammad Amin Mahdian, Mohammad Saeid Ebrahimi, Mohammad Taghizadieh, Massoud Vosough, Javid Sadri Nahand, Saereh Hosseindoost, Nasim Vousooghi, Hamid Akbari Javar, Bagher Larijani, Mahmoud Reza Hadjighassem, Neda Rahimian, Michael R. Hamblin and Hamed Mirzaei

Molecular Therapy - Nucleic Acids, 2022, 28, 758
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Plasmonic and Electrostatic Interactions Enable Uniformly Enhanced Liquid Bacterial Surface-Enhanced Raman Scattering (SERS)

Loza F. Tadesse, Chi-Sing Ho, Dong-Hua Chen, Hamed Arami, Niaz Banaei, Sanjiv S. Gambhir, Stefanie S. Jeffrey, Amr A. E. Saleh and Jennifer Dionne

Nano Lett., 2020, 20, 7655
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Direct On-Analyte Fabrication of Au Nanoparticles for Substrate-Free SERS Detection of Micro and Nanoplastics

Ayoub Laghrissi, Horst-Günter Rubahn and Jacek Fiutowski

ACS Omega, 2025, 10, 38474
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Hyperspectral spatially offset Raman spectroscopy in a microfluidic channel

Moritz Matthiae and Anders Kristensen

Opt. Express, 2019, 27, 3782
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Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy

Jonathan J. S. Rickard, Valentina Di-Pietro, David J. Smith, David J. Davies, Antonio Belli and Pola Goldberg Oppenheimer

Nat Biomed Eng, 2020, 4, 610
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TopUp SERS Substrates with Integrated Internal Standard

Sophie Patze, Uwe Huebner, Karina Weber, Dana Cialla-May and Juergen Popp

Materials, 2018, 11, 325
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SERS Barcode Libraries: A Microfluidic Approach

Semih Sevim, Carlos Franco, Xiang‐Zhong Chen, Alessandro Sorrenti, David Rodríguez‐San‐Miguel, Salvador Pané, Andrew J. deMello and Josep Puigmartí‐Luis

Advanced Science, 2020, 7
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Nanocone—versatile nanofiller for cutting-edge polymeric nanocomposite

Ayesha Kausar

Polymer-Plastics Technology and Materials, 2022, 61, 989
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Combination of liquid‐based column separations with surface‐enhanced Raman spectroscopy

Anna Týčová and Karel Klepárník

J of Separation Science, 2019, 42, 431
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Simultaneous and highly sensitive detection of multiple breast cancer biomarkers in real samples using a SERS microfluidic chip

Zhihua Zheng, Lei Wu, Lang Li, Shenfei Zong, Zhuyuan Wang and Yiping Cui

Talanta, 2018, 188, 507
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Surface-Enhanced Raman Scattering on Silver Sinusoidal Nanograting: Impact of Interactions of Grating-Coupled Surface Plasmon Polaritons

Zhaoyi Chen, Ke Feng, Zhibin Chen, Jinxing Shen and Huanliang Li

Plasmonics, 2022, 17, 757
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In Situ Microfluidic SERS Chip for Ultrasensitive Hg2+ Sensing Based on I–-Functionalized Silver Aggregates

Huijuan Zhang, Dong Wang, Duan Zhang, Tongtong Zhang, Longkun Yang and Zhipeng Li

ACS Appl. Mater. Interfaces, 2022, 14, 2211
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Current methods and emerging approaches for detection of programmed death ligand 1

Qiang Chen, Junjie Hu, Xiaojun Hu, Kwangnak Koh and Hongxia Chen

Biosensors and Bioelectronics, 2022, 208, 114179
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Label-Free Sensing in Microdroplet-Based Microfluidic Systems

Ali Kalantarifard, Abtin Saateh and Caglar Elbuken

Chemosensors, 2018, 6, 23
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Surface‐Enhanced Raman Scattering for Rapid Detection and Characterization of Antibiotic‐Resistant Bacteria

Daniel D. Galvan and Qiuming Yu

Adv Healthcare Materials, 2018, 7
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Detection of food spoilage and adulteration by novel nanomaterial-based sensors

Zahra Mohammadi and Seid Mahdi Jafari

Advances in Colloid and Interface Science, 2020, 286, 102297
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Recent Developments in SERS Microfluidic Chips: From Fundamentals to Biosensing Applications

Shuai Lian, Xiaoqiong Li and Xuefei Lv

ACS Appl. Mater. Interfaces, 2025, 17, 10193
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Microfluidic Devices for Label-Free DNA Detection

Gorachand Dutta, Joshua Rainbow, Uros Zupancic, Sotirios Papamatthaiou, Pedro Estrela and Despina Moschou

Chemosensors, 2018, 6, 43
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High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology

Liangliang Yang, Sara Pijuan-Galito, Hoon Suk Rho, Aliaksei S. Vasilevich, Aysegul Dede Eren, Lu Ge, Pamela Habibović, Morgan R. Alexander, Jan de Boer, Aurélie Carlier, Patrick van Rijn and Qihui Zhou

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Advances in droplet microfluidics for SERS and Raman analysis

Shuai Yue, Jin Fang and Zhangrun Xu

Biosensors and Bioelectronics, 2022, 198, 113822
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Spectral flow cytometry based on integration of surface-enhanced Raman scattering nanoprobes with microfluidic chip for detection of bacteria

Zhong-Hao Fong, Chih-Hsien Wang, Chiou-Ying Yang, Hung-Chih Kan, Yi-Jyun Lin, Yen-Ling Chen, Yi-Chen Shen, Yun-Chi Yu, Lai-Kwan Chau, Chong-Wai Io and Shau-Chun Wang

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Emerging Trends in Microfluidics Based Devices

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Biotechnology Journal, 2020, 15
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Simultaneous detection of urea and lactate in sweat based on a wearable sweat biosensor

Haifan Yang, Yangyang Ji, Kang Shen, Yayun Qian and Chenchen Ye

Biomed. Opt. Express, 2024, 15, 14
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An opto-acousto-fluidic microchip for efficient Raman spectroscopy of microparticles in aqueous environment

Mehrdad Lotfi Choobbari, Margot Vandermotten, Tatevik Chalyan, Ilyesse Bihi, Pierre Gelin, Wim De Malsche, Wendy Meulebroeck, Leo A. van Grunsven, Hugo Thienpont and Heidi Ottevaere

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Surface-enhanced Raman spectroscopy

Xiao Xia Han, Rebeca S. Rodriguez, Christy L. Haynes, Yukihiro Ozaki and Bing Zhao

Nat Rev Methods Primers, 2022, 1
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Towards a portable setup for the on-site SERS detection of miRNAs

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Hemozoin in malaria eradication—from material science, technology to field test

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Recent Advances in Sandwich SERS Immunosensors for Cancer Detection

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A universal CRISPR/Cas12a-mediated AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform for virus gene detection

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Copper nanostructures for chemical analysis using surface-enhanced Raman spectroscopy

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The latest advances in high content screening in microfluidic devices

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