Issue 7, 2021

AIE-nanoparticle assisted ultra-deep three-photon microscopy in the in vivo mouse brain under 1300 nm excitation

Abstract

Aggregation-induced emission nanoparticles serve as promising fluorescence probes for multi-photon excitation microscopy due to the large absorption cross-section in the NIR-IIb region. Here we present organic AIE nanoparticles that feature a high absorption cross-section under three-photon excitation. We show that these enable ultra-deep NIR-IIa excited three-photon imaging in the in vivo mouse brain.

Graphical abstract: AIE-nanoparticle assisted ultra-deep three-photon microscopy in the in vivo mouse brain under 1300 nm excitation

Article information

Article type
Research Article
Submitted
10 feb. 2021
Accepted
25 feb. 2021
First published
25 feb. 2021

Mater. Chem. Front., 2021,5, 3201-3208

AIE-nanoparticle assisted ultra-deep three-photon microscopy in the in vivo mouse brain under 1300 nm excitation

D. Li, H. Zhang, L. L. Streich, Y. Wang, P. Lu, L. Wang, R. Prevedel and J. Qian, Mater. Chem. Front., 2021, 5, 3201 DOI: 10.1039/D1QM00243K

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