Issue 19, 2021

Ball-milling synthesis of sulfonyl quinolines via coupling of haloquinolines with sulfonic acids

Abstract

An efficient and practical approach for the synthesis of sulfonyl quinolines via ball milling promoted coupling of haloquinolines with sulfonic acid under metal-, solvent- and additive-free conditions has been developed. In contrast to the solvent-based sulfonylation reactions, this protocol has the advantage of shorter reaction time (10–20 min), mild reaction temperature, operational simplicity and excellent to quantitative yields, making this method very attractive for the preparation of sulfonyl quinoline compounds.

Graphical abstract: Ball-milling synthesis of sulfonyl quinolines via coupling of haloquinolines with sulfonic acids

Supplementary files

Article information

Article type
Paper
Submitted
07 jun. 2021
Accepted
09 jul. 2021
First published
09 jul. 2021

Green Chem., 2021,23, 7589-7593

Ball-milling synthesis of sulfonyl quinolines via coupling of haloquinolines with sulfonic acids

X. Liu, J. Wang, H. Ma, Q. Zhu and L. Xie, Green Chem., 2021, 23, 7589 DOI: 10.1039/D1GC02015C

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