Chromium-catalyzed transformations with Grignard reagents – new opportunities for cross-coupling reactions

Abstract

Beyond classic Nozaki–Hiyama–Kishi reactions, a low-cost and low-toxicity chromium(II) salt was recently shown to have the capability to catalyze the cross-couplings of C–X and C–H bonds with Grignard reagents. It is a remarkable progression and would point to a new direction for future development of chromium catalysis, as well as opening new opportunities for discovery of new cross-coupling reactions. This highlight focuses on these advances in chromium-catalyzed transformations using Grignard reagents.