Issue 25, 2024

Development of a specific fluorescent probe to detect advanced glycation end products (AGEs)

Abstract

Advanced glycation end products (AGEs) play a pivotal role in the aging process, regarded as a hallmark of aging. Despite their significance, the absence of adequate monitoring tools has hindered the exploration of the relationship between AGEs and aging. Here, we present a novel AGE-selective probe, AGO, for the first time. AGO exhibited superior sensitivity in detecting AGEs compared to the conventional method of measuring autofluorescence from AGEs. Furthermore, we validated AGO's ability to detect AGEs based on kinetics, demonstrating a preference for ribose-derived AGEs. Lastly, AGO effectively visualized glycation products in a collagen-based mimicking model of glycation. We anticipate that this study will enhance the molecular tool sets available for comprehending the physiological processes of AGEs during aging.

Graphical abstract: Development of a specific fluorescent probe to detect advanced glycation end products (AGEs)

Supplementary files

Article information

Article type
Paper
Submitted
21 mar. 2024
Accepted
22 may. 2024
First published
23 may. 2024
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2024,12, 6155-6163

Development of a specific fluorescent probe to detect advanced glycation end products (AGEs)

H. Cho, N. Hong, I. Yong, H. Kwon, N. Kang, L. M. Ciaramicoli, P. Kim and Y. Chang, J. Mater. Chem. B, 2024, 12, 6155 DOI: 10.1039/D4TB00590B

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