Issue 7, 2024

Unlocking the potential of metal ligand cooperation for enantioselective transformations

Abstract

Metal–ligand cooperation, in which both the metal and the ligand of a transition metal complex actively participate in chemical transformations leading to enhanced reactivity or selectivity in chemical reactions, has emerged as a powerful and versatile concept in catalysis. This Viewpoint discusses the development trajectory of transition metal-based complexes as catalysts in (de)hydrogenative processes, in particular those cases where metal–ligand cooperation has been invoked to rationalise the observed high reactivities and excellent selectivities. The historical context, mechanistic aspects and current applications are discussed with the suggestion to explore the potential of the MLC mode of action of such catalysts in enantioselective transformations beyond (de)hydrogenative processes.

Graphical abstract: Unlocking the potential of metal ligand cooperation for enantioselective transformations

Article information

Article type
Viewpoint
Submitted
14 nov. 2023
First published
21 feb. 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2024,53, 3216-3223

Unlocking the potential of metal ligand cooperation for enantioselective transformations

T. Ramspoth, J. Kootstra and S. R. Harutyunyan, Chem. Soc. Rev., 2024, 53, 3216 DOI: 10.1039/D3CS00998J

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