Issue 35, 2023

Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

Abstract

The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and metal ions, all playing a role. Here we report a strategic approach to designing flavonoids that can effectively tackle multiple pathological elements involved in AD. Our systematic investigations revealed key structural features for flavonoids to simultaneously target and regulate pathogenic targets. Our findings led to the development of a highly promising flavonoid that exhibits a range of functions, based on a complete structure–activity relationship analysis. Furthermore, our mechanistic studies confirmed that this flavonoid's versatile reactivities are driven by its redox potential and direct interactions with pathogenic factors. This work highlights the potential of multi-target-directed flavonoids as a novel solution in the fight against AD.

Graphical abstract: Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

Supplementary files

Article information

Article type
Edge Article
Submitted
10 feb. 2023
Accepted
02 ago. 2023
First published
03 ago. 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 9293-9305

Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

S. Park, M. Kim, Y. Lin, M. Hong, G. Nam, A. Mieczkowski, J. Kardos, Y. Lee and M. H. Lim, Chem. Sci., 2023, 14, 9293 DOI: 10.1039/D3SC00752A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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