Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Laura Rijns; Lu Su; Konrad Maxeiner; Giulia Morgese; David Y. W. Ng; Tanja Weil; Patricia Y. W. Dankers

doi:10.1039/D2CC06064G

Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels†

Laura Rijns,

^abc Lu Su,

*^d Konrad Maxeiner,^e Giulia Morgese,^f David Y. W. Ng,

^e Tanja Weil^e and Patricia Y. W. Dankers

*^abc

Author affiliations

* Corresponding authors

^a Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands
E-mail: p.y.w.dankers@tue.nl

^b Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

^c Department of Biomedical Engineering, Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

^d Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands
E-mail: l.su@lacdr.leidenuniv.nl

^e Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany

^f ZHAW Zurich University of Applied Sciences, School of Engineering, Forschungsbereich Polymere Beschichtungen, Technikumstrasse 9, Winterthur 8400, Switzerland

Abstract

Benzene-1,3,5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.

This article is part of the themed collection: Celebrating 10 years of ChemComm Emerging Investigators

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DOI: https://doi.org/10.1039/D2CC06064G
Article type: Communication
Submitted: 14 nov. 2022
Accepted: 16 ene. 2023
First published: 31 ene. 2023
This article is Open Access

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Chem. Commun., 2023,59, 2090-2093

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Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

L. Rijns, L. Su, K. Maxeiner, G. Morgese, D. Y. W. Ng, T. Weil and P. Y. W. Dankers, Chem. Commun., 2023, 59, 2090 DOI: 10.1039/D2CC06064G

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Chemical Communications

Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels†

Abstract

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Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

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