Issue 46, 2022

Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing

Abstract

Skin wounds are a common condition causing economic burden and they represent an urgent clinical need, especially chronic wounds. Numerous studies have been conducted on the applications of stem cell therapy in wound healing, with adipose-derived mesenchymal stem cells (ADMSCs) playing a major role since they can be isolated easily, yielding a high number of cells, the less invasive harvesting required, the longer life span and no ethical issues. However, the lack of standardized doses and protocols, the heterogeneity of clinical trials, as well as the incompatibility of the immune system limit its application. Recent studies have demonstrated that specific stem cell functions depend on paracrine factors, including extracellular vesicles, in which microRNAs in exosomes (Exo-miRNAs) are essential in controlling their functions. This paper describes the application and mechanism whereby ADMSC-Exo-miRNA regulates wound healing. ADMSC-Exo-miRNA is involved in various stages in wounds, including modulating the immune response and inflammation, accelerating skin cell proliferation and epithelialization, promoting vascular repair, and regulating collagen remodeling thereby reducing scar formation. In summary, this acellular therapy based on ADMSC-Exo-miRNA has considerable clinical potential, and provides reference values for developing new treatment strategies for wound healing.

Graphical abstract: Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing

Article information

Article type
Review Article
Submitted
18 sep. 2022
Accepted
21 oct. 2022
First published
24 oct. 2022

J. Mater. Chem. B, 2022,10, 9565-9577

Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing

J. Ma, L. Yong, P. Lei, H. Li, Y. Fang, L. Wang, H. Chen, Q. Zhou, W. Wu, L. Jin, D. Sun and X. Zhang, J. Mater. Chem. B, 2022, 10, 9565 DOI: 10.1039/D2TB01987F

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