Issue 43, 2022

Current status and future prospects of nanoscale metal–organic frameworks in bioimaging

Abstract

The importance of the early-stage diagnosis and in situ monitoring of lesion regions and transportation of bioactive molecules has a pivotal effect on successful treatment, reducing side effects, and increasing the chances of survival in the case of serious diseases such as cancer. This strongly depends on the development of contrast agents and biomarkers together with the appropriate use of bioimaging techniques. Because of their exceptionally high surface area and porosity, nanoscale metal–organic frameworks (NMOFs) have been the subject of numerous studies in the biomedical domain as drug carriers, diagnostic and therapeutic agents, and biosensors. This review provides a summary of the recent advancements in the use of MOFs as nanoscale platforms for biomedical imaging via magnetic resonance (MR) imaging, computed tomography (CT), single-photon emission computed tomography (SPECT), fluorescence (FL) imaging, positron emission tomography (PET), photoacoustic (PA) imaging, and photothermal (PT) imaging modalities. Initially, we describe the principles of a specific imaging technique in each section, and then present the recent reports on MOFs for monomodal and multimodal imaging and the following information: (i) how to synthesize MOFs and modify their surface and (ii) their utilization in bioimaging or theranostic applications.

Graphical abstract: Current status and future prospects of nanoscale metal–organic frameworks in bioimaging

Article information

Article type
Review Article
Submitted
22 ago. 2022
Accepted
01 oct. 2022
First published
05 oct. 2022

J. Mater. Chem. B, 2022,10, 8824-8851

Current status and future prospects of nanoscale metal–organic frameworks in bioimaging

M. Nazari, A. Sh. Saljooghi, M. Ramezani, M. Alibolandi and M. Mirzaei, J. Mater. Chem. B, 2022, 10, 8824 DOI: 10.1039/D2TB01787C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements