Issue 31, 2022

Tannic acid: a versatile polyphenol for design of biomedical hydrogels

Abstract

Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic acid with several galloyl groups in its structure. Tannic acid interacts with various organic, inorganic, hydrophilic, and hydrophobic materials such as proteins and polysaccharides via hydrogen bonding, electrostatic, coordinative bonding, and hydrophobic interactions. Tannic acid has been studied for various biomedical applications as a natural crosslinker with anti-inflammatory, antibacterial, and anticancer activities. In this review, we focus on TA-based hydrogels for biomaterials engineering to help biomaterials scientists and engineers better realize TA's potential in the design and fabrication of novel hydrogel biomaterials. The interactions of TA with various natural or synthetic compounds are deliberated, discussing parameters that affect TA–material interactions thus providing a fundamental set of criteria for utilizing TA in hydrogels for tissue healing and regeneration. The review also discusses the merits and demerits of using TA in developing hydrogels either through direct incorporation in the hydrogel formulation or indirectly via immersing the final product in a TA solution. In general, TA is a natural bioactive molecule with diverse potential for engineering biomedical hydrogels.

Graphical abstract: Tannic acid: a versatile polyphenol for design of biomedical hydrogels

Article information

Article type
Review Article
Submitted
18 may. 2022
Accepted
09 jul. 2022
First published
13 jul. 2022

J. Mater. Chem. B, 2022,10, 5873-5912

Tannic acid: a versatile polyphenol for design of biomedical hydrogels

H. Jafari, P. Ghaffari-Bohlouli, S. V. Niknezhad, A. Abedi, Z. Izadifar, R. Mohammadinejad, R. S. Varma and A. Shavandi, J. Mater. Chem. B, 2022, 10, 5873 DOI: 10.1039/D2TB01056A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements