Issue 2, 2022

Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C[double bond, length as m-dash]C–N donors

Abstract

Nitrogen-containing heterocycles are ubiquitous fragments of numerous natural products, pharmaceuticals, designed bioactive drug candidates and agrochemicals. During the past few decades, these compounds have received considerable attention from the synthetic chemistry community, and great efforts have been focused on the development of concise and efficient methods for the synthesis of these heterocyclic skeletons. In this review, we summarize a diverse range of synthetic methods employing β-aminovinyl esters(ketones) as key C[double bond, length as m-dash]C–N-synthons to furnish useful bioactive heterocyclic frameworks, such as quinolines, pyridines, pyrazines, pyrroles, indoles, oxazoles, imidazoles, thiazoles, isothiazoles, pyrazoles, triazoles, and azepines, thus offering new opportunities and expanding the toolbox of synthetic chemistry reactions.

Graphical abstract: Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C [[double bond, length as m-dash]] C–N donors

Article information

Article type
Review Article
Submitted
12 oct. 2021
Accepted
19 nov. 2021
First published
19 nov. 2021

Org. Biomol. Chem., 2022,20, 282-295

Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C[double bond, length as m-dash]C–N donors

X. Xia and Y. Niu, Org. Biomol. Chem., 2022, 20, 282 DOI: 10.1039/D1OB01998H

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