Issue 44, 2021

Nanomedicine to advance the treatment of bacteria-induced acute lung injury

Abstract

Bacteria-induced acute lung injury (ALI) is associated with a high mortality rate due to the lack of an effective treatment. Patients often rely on supportive care such as low tidal volume ventilation to alleviate the symptoms. Nanomedicine has recently received much attention owing to its premium benefits of delivering drugs in a sustainable and controllable manner while minimizing the potential side effects. It can effectively improve the prognosis of bacteria-induced ALI through targeted delivery of drugs, regulation of multiple inflammatory pathways, and combating antibiotic resistance. Hence, in this review, we first discuss the pathogenesis of ALI and its potential therapeutics. In particular, the state-of-the-art nanomedicines for the treatment of bacteria-induced ALI are highlighted, including their administration routes, in vivo distribution, and clearance. Furthermore, the available bacteria-induced ALI animal models are also summarized. In the end, future perspectives of nanomedicine for ALI treatment are proposed.

Graphical abstract: Nanomedicine to advance the treatment of bacteria-induced acute lung injury

Article information

Article type
Review Article
Submitted
13 ago. 2021
Accepted
28 sep. 2021
First published
28 sep. 2021

J. Mater. Chem. B, 2021,9, 9100-9115

Nanomedicine to advance the treatment of bacteria-induced acute lung injury

R. Su, Y. Zhang, J. Zhang, H. Wang, Y. Luo, H. F. Chan, Y. Tao, Z. Chen and M. Li, J. Mater. Chem. B, 2021, 9, 9100 DOI: 10.1039/D1TB01770E

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