Issue 34, 2021

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

Abstract

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor hypoxia microenvironments could severely reduce the efficacy of oxygen-consuming phototherapies. Perfluorocarbon (PFC) nanomaterials have shown great practical value in carrying and transporting oxygen, which makes them promising agents to overcome tumor hypoxia and extend reactive oxygen species (ROS) lifetime to improve the efficacy of phototherapy. In this review, we summarize the latest advances in PFC-based PDT and PTT, and combined multimodal imaging technologies in various cancer types, aiming to facilitate their application-oriented clinical translation in the future.

Graphical abstract: Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

Article information

Article type
Review Article
Submitted
14 mar. 2021
Accepted
28 jul. 2021
First published
29 jul. 2021

J. Mater. Chem. B, 2021,9, 6751-6769

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

Z. Han, X. Tu, L. Qiao, Y. Sun, Z. Li, X. Sun and Z. Wu, J. Mater. Chem. B, 2021, 9, 6751 DOI: 10.1039/D1TB00554E

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