Issue 4, 2021

Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Abstract

Single-component nanoplatforms combined with the second near-infrared optical window (NIR-II, 1000–1700 nm) fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) have received increasing attention owing to their capacity for precise diagnosis, noninvasive therapy, and real-time monitoring of the therapeutic effects. However, most of the PTT treatments are performed in the NIR-I window (700–900 nm). Moreover, the design and development of conjugated polymers (P1, P2, and P3) with both bright NIR-II fluorescence and superior NIR-II photothermal effect remained a huge challenge. Therefore, three double-acceptor conjugated polymers were designed and developed by adjusting the molar ratios of two acceptors, TTQ and DPP. Subsequently, their corresponding nanoparticles were fabricated, and finally, nanoparticles based on the conjugated polymer P1 (P1 NPs) with both high NIR-II fluorescence intensity and superior NIR-II photothermal efficiency were selected and applied for NIR-II FI and NIR-II PTT. Importantly, the experiments of in vivo NIR-II FI and NIR-II PTT demonstrated that P1 NPs exhibited not only high accumulation in the tumour sites and high sign-to-background ratio (SBR) of vascular imaging, but also superior NIR-II PTT efficiency for tumour treatment.

Graphical abstract: Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Supplementary files

Article information

Article type
Paper
Submitted
22 oct. 2020
Accepted
01 dic. 2020
First published
09 dic. 2020

J. Mater. Chem. B, 2021,9, 1002-1008

Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Y. Chen, B. Sun, X. Jiang, Z. Yuan, S. Chen, P. Sun, Q. Fan and W. Huang, J. Mater. Chem. B, 2021, 9, 1002 DOI: 10.1039/D0TB02499F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements