Issue 5, 2020

Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors

Abstract

The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection. In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug discovery. The following review discusses the efforts made in the field to isolate and identify natural products as inhibitors of the proteasome. In addition, we describe some of the modifications made to natural products in order to discover more potent and selective inhibitors for potential disease treatment.

Graphical abstract: Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors

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Article information

Article type
Review Article
Submitted
29 jun. 2020
Accepted
01 sep. 2020
First published
16 sep. 2020
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2020,1, 305-332

Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors

G. E. Hubbell and J. J. Tepe, RSC Chem. Biol., 2020, 1, 305 DOI: 10.1039/D0CB00111B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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