Issue 19, 2019

Silver-catalyzed decarboxylative radical cascade cyclization toward benzimidazo[2,1-a]isoquinolin-6(5H)-ones

Abstract

A simple and efficient decarboxylative radical addition/cyclization strategy was developed, by which a wide range of benzimidazo[2,1-a]isoquinoline-6(5H)-ones were prepared in one-pot via reaction of functionalized 2-arylbenzoimidazoles and carboxylic acids in the presence of K2S2O8/AgNO3 under mild reaction conditions.

Graphical abstract: Silver-catalyzed decarboxylative radical cascade cyclization toward benzimidazo[2,1-a]isoquinolin-6(5H)-ones

Supplementary files

Article information

Article type
Communication
Submitted
28 dic. 2018
Accepted
04 feb. 2019
First published
04 feb. 2019

Chem. Commun., 2019,55, 2861-2864

Silver-catalyzed decarboxylative radical cascade cyclization toward benzimidazo[2,1-a]isoquinolin-6(5H)-ones

K. Sun, S. Li, X. Chen, Y. Liu, X. Huang, D. Wei, L. Qu, Y. Zhao and B. Yu, Chem. Commun., 2019, 55, 2861 DOI: 10.1039/C8CC10243K

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