Issue 2, 2017

Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

Abstract

Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary to obtain information about its mechanism using a carbon paste electrode (CPE) modified with chitosan (Cs)/multi-walled carbon nanotubes (CNT) and cobalt nanoparticles (CoNps). The simultaneous determination of DAC with the hepatitis B antiviral drug entecavir (ENT) was also investigated by differential pulse voltammetry in universal buffer pH 2.0. The experimental results specify a linear relation between the DAC peak current and its concentration in the range from 1.0 nM to 12 μM, leading to a detection limit of 8.82 × 10−10 M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.

Graphical abstract: Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

Article information

Article type
Paper
Submitted
25 oct. 2016
Accepted
28 nov. 2016
First published
04 ene. 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 1118-1126

Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

Shereen M. Azab and A. M. Fekry, RSC Adv., 2017, 7, 1118 DOI: 10.1039/C6RA25826C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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