Issue 5, 2016

Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

Abstract

Covering: 1992 to 2015

The natural products FR901464, pladienolide, and herboxidiene were discovered as activators of reporter gene systems. Unexpectedly, these compounds target neither transcription nor translation; rather, they target splicing factor 3B subunit 1 of the spliceosome, causing changes in splicing patterns. All of them showed anticancer activity in a low nanomolar range. Since their discovery, these molecules have been used in a variety of biological applications.

Graphical abstract: Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

Article information

Article type
Highlight
Submitted
07 sep. 2015
First published
26 ene. 2016

Nat. Prod. Rep., 2016,33, 637-647

Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

D. Pham and K. Koide, Nat. Prod. Rep., 2016, 33, 637 DOI: 10.1039/C5NP00110B

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