Issue 43, 2021

Perylene diimide-based treatment and diagnosis of diseases

Abstract

Integrated treatment using imaging technology to monitor biological processes for the precise treatment and diagnosis of diseases to improve treatment outcomes is becoming a hot topic. Accordingly, perylene diimide (PDI) has excellent photothermal conversion and photostability, which can be used as a good material for disease treatment and diagnosis. Herein, we review the latest research progress on the real-time diagnosis of related diseases based on perylene diimide probes in the aspects of bioimaging, detection of biomarkers and determination of the pH in living cells. Furthermore, perylene diimide-based multifunctional nano-delivery systems are particularly emphasized, showing great therapeutic potential in the field of image-guided combination therapy in tumor therapy. Finally, the great opportunities and challenges still faced by perylene diimide before entering the clinic are comprehensively analyzed.

Graphical abstract: Perylene diimide-based treatment and diagnosis of diseases

Article information

Article type
Review Article
Submitted
11 ago. 2021
Accepted
27 sep. 2021
First published
30 sep. 2021

J. Mater. Chem. B, 2021,9, 8937-8950

Perylene diimide-based treatment and diagnosis of diseases

Z. Zhao, N. Xu, Y. Wang, G. Ling and P. Zhang, J. Mater. Chem. B, 2021, 9, 8937 DOI: 10.1039/D1TB01752G

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