Issue 7, 2020

Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

Abstract

In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most phototoxic (at 2.5 μM) towards B16F10 cells.

Graphical abstract: Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

Supplementary files

Article information

Article type
Paper
Submitted
26 mar. 2020
Accepted
18 may. 2020
First published
19 may. 2020

Photochem. Photobiol. Sci., 2020,19, 885-891

Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

K. A. D. F. Castro, L. D. Costa, S. Guieu, J. C. Biazzotto, M. D. G. P. M. S. Neves, M. A. F. Faustino, R. S. da Silva and A. C. Tomé, Photochem. Photobiol. Sci., 2020, 19, 885 DOI: 10.1039/D0PP00114G

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