Issue 2, 2019

Immobilized tetrakis(triphenylphosphine)palladium(0) for Suzuki–Miyaura coupling reactions under flow conditions

Abstract

An immobilized triphenylphosphine scaffold was prepared by precipitation polymerization and functionalized to afford a cost-effective source of solid-supported tetrakis(triphenylphosphine)palladium(0). The catalyst was characterised and used to perform biphasic Suzuki–Miyaura cross-coupling reactions using a packed-bed reactor under flow conditions. The approach afforded comparable yields to those obtained under batch conditions with a single pass through the packed-bed reactor (1 h vs. 18 h). The use of a recycling system was investigated on a model reaction and found to afford close to quantitative conversion within 3 hours.

Graphical abstract: Immobilized tetrakis(triphenylphosphine)palladium(0) for Suzuki–Miyaura coupling reactions under flow conditions

Supplementary files

Article information

Article type
Paper
Submitted
02 oct. 2018
Accepted
03 dic. 2018
First published
03 dic. 2018

React. Chem. Eng., 2019,4, 372-382

Immobilized tetrakis(triphenylphosphine)palladium(0) for Suzuki–Miyaura coupling reactions under flow conditions

G. V. Ramaotsoa, I. Strydom, J. Panayides and D. Riley, React. Chem. Eng., 2019, 4, 372 DOI: 10.1039/C8RE00235E

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