Issue 24, 2013

Nanoscale organization of proteinsviablock copolymerlithography and non-covalent bioconjugation

Abstract

Thin films of cylinder-forming biotinylated poly(ethylene glycol)-polystyrene (PEG-b-PS) block copolymers were studied as a means to produce protein patterns. The orientation of the PEG cylinders depended on the end group functionality as well as on the preparation conditions. In the case of perpendicular cylinders, immobilization of single streptavidin molecules could be achieved. This immobilization was controlled by varying the amount of biotin in the films by mixing with non-functional PEG-b-PS.

Graphical abstract: Nanoscale organization of proteins via block copolymer lithography and non-covalent bioconjugation

Supplementary files

Article information

Article type
Communication
Submitted
24 mar. 2013
Accepted
01 may. 2013
First published
01 may. 2013

J. Mater. Chem. B, 2013,1, 3026-3030

Nanoscale organization of proteins via block copolymer lithography and non-covalent bioconjugation

I. C. Reynhout, G. Delaittre, H. Kim, R. J. M. Nolte and J. J. L. M. Cornelissen, J. Mater. Chem. B, 2013, 1, 3026 DOI: 10.1039/C3TB20411A

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