RSC Advances  

The dihydrobenzofuran scaffolds demonstrate a wide range of biological activities. Several transition metals have been employed as catalysts for the efficacious synthesis of these structurally important frameworks.

A Ts₂O promoted deoxygenative C2-dithiocarbamation of quinoline N-oxides with CS₂ and amines toward various quinoline-dithiocarbamates under transition-metal free conditions was developed.

The synthesis of amines through N-alkylation is particularly attractive.

The copper-free azide–alkyne click reaction has shown to be a successful alternative to immobilize covalently a fluorescente compound onto poly(-L-lactic) acid (PLLA) surfaces.

Synthesis of mono- and bis-thiosemicarbazones 4a–h and 5a–h of isatin–triazole hybrids 3a and 3b in turn accessed via CuAAC, their DFT studies and potential as phosphoinositide 3-kinase (PI3K) inhibitors has been evaluated in this study.

2-N-Substituted indenones, cyclopentenones or 4-carbonyl oxazoles are prepared from 5-acylated N-fluoroalkyl substituted 1,2,3-triazoles and Lewis acids.

Phenoxathiin-based macrocycles react with RLi reagents to form a number of different products resulting from cleavage of the calixarene backbone or heterocyclic group.

An exceptional achiral and chiral multilayer 3D polymer has been created and controlled by uniform and distinct aromatic chromophore units that are multiply sandwiched by naphthyl berths.

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.

A novel protocol for introducing an acetoxy functional group selectively on the ortho aryl sp² carbon of 2-aryloxyquinoline-3-carbaldehydes in good yields with good functional group tolerance using a palladium catalyst was developed for the first time.

3-Carboxamide indazoles have been developed using the amide coupling process. Density function theory (DFT) computations, and the assessment of binding energy using Auto Dock, illustrate the pharmaceutical effectiveness.

The mechanochemical synthesis of AIE-active amide, as well as the application of the title compound as molecular receptor of monovalent anions and nucleotides, are described.

An efficient and mild approach has been developed for the regio-selective direct C3 halogenation of pyrazolo[1,5-a]pyrimidines employing readily available potassium halide salts and a hypervalent iodine(III) reagent at ambient temperature.

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

New conjugates 1–6 containing 5-dFCR and selected hydroxycinnamic acids were synthesized and tested in vitro against pancreatic cancer (PDAC) lines. The ADME properties and molecular docking to CES2 or human albumin were discussed.

This work describes the manganese catalyzed direct coupling of nitriles with alcohols with assistance of a set of simple and new imidazole-based N,N-bidentate ligands.

Nickel-catalyzed cross-electrophile coupling of cyclopropyl ketones and alkyl chlorides. High reactivity and selectivity can be achieved with sodium iodide as a cocatalyst that generates a low concentration of alkyl iodide via halide exchange.

Starch as catalyst for organic reactions.

A mild, efficient and convenient procedure for the acetylation of alcohols with EtOAc as acetyl source and solvent mediated by KOH was reported.

An electrochemical approach to access seleno-benzazepines through an oxidative radical cascade cyclization of dienes with diselenides under metal-free, external oxidant-free and base-free conditions.

Oxamic acids where shown to add to imines, providing a broad range of α-aminoacid amides in generally good yields.

An overview on the mechanism of Pseudomonas aeruginosa PAO1 biofilm inhibition by Suzuki–Miyaura coupled flavonols.

A LED-induced Ru-photoredox Pd-catalyzed method was employed to carry out late-stage C–H arylation on a series of Biginelli/Suzuki-derived modular (6-phenylpyridin-2-yl)pyrimidine substrates and their heteroaryl counterparts.

Bicyclic guanidines are utilized in organic synthesis as base catalysts or reagents.

Using a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.