RSC Advances  

The emergence and spread of antibiotic-resistant (AR) bacterial strains and biofilm-associated diseases have heightened concerns about exploring alternative bactericidal methods.

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of the nanoparticle-hydrogels system for the delivery of antimicrobial agents.

The rapid emergence of MDR Klebsiella pneumoniae demands alternative therapy. 6-Gingerol is a natural phytocompound that has synergistic and bactericidal effects against MDR-KP isolates. It exhibited promising EPI activity to stop colistin efflux.

Christella dentata (Forssk.) Brownsey & Jermy has been commonly used in traditional medicinal practices but its effects on multi-drug-resistant (MDR) bacteria have remained unexplored.

SERS with silver nanoparticles analyzes effects of Siphoviridae bacteriophages on bacteria (Staphylococcus aureus), providing insights into phage-bacteria interactions.

This work describes novel transaminase fusions, with potential for converting fatty acids into amines and more complex natural products.

Potent DNA gyrase and topoisomerase IV inhibitor bearing a siderophore mimic moiety displays improved antibacterial activity against Escherichia coli under iron-depleted conditions.

We developed modular antimicrobial compounds capable of inducing cytoplasmic membrane perforation. This structure–activity relationship study focuses on the role of the length of their alkenyl hydrophobic module.

Indirect labelling of the lipopolysaccharide of Gram-negative bacteria by fluorescence turn-on signalling and computational calculations.

The level of heat resistance in microbial cells is an important factor in determining the energy consumption and product synthesis efficiency of fermentation processes.

The 4-MHA, a key node in the biosynthetic flow of actinomycins under NRPS catalysis, is also converted into actinrhaters A and B.

Antimicrobial resistance (AMR), a condition in which the efficacy of antimicrobial drugs in fighting microorganisms is reduced, has become a global challenge.

The biological reduction of selenite (Se(IV)) or tellurite (Te(IV)) to Se⁰ or Te⁰ has received increasing attention, as related studies have favored the development of Se/Te pollution control methods.

After conducting an in silico analysis of the cryptic mdk cluster region and performing transcriptomic studies, an integrative Streptomyces BAC Vector containing the mdk gene sequence was constructed and heterologous expression yielded the angucyclic product seongomycin.