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Themed collection Natural Product Reports Emerging Investigator Lectureship winners

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Neurite outgrowth enhancement by jiadifenolide: possible targets

A mechanistic link may exist between convulsant plant substances typified by picrotoxinin, and ‘neurotrophic’ sesquiterpenes like jiadifenolide.

Graphical abstract: Neurite outgrowth enhancement by jiadifenolide: possible targets
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Colibactin: understanding an elusive gut bacterial genotoxin

This highlight reviews recent studies of colibactin, a structurally uncharacterized genotoxin synthesized by members of the human gut microbiota.

Graphical abstract: Colibactin: understanding an elusive gut bacterial genotoxin
Review Article

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products

Over the centuries, microbial secondary metabolites have played a central role in the treatment of human diseases and have revolutionised the pharmaceutical industry.

Graphical abstract: Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products
Review Article

The diazofluorene antitumor antibiotics: Structural elucidation, biosynthetic, synthetic, and chemical biological studies

The kinamycins and lomaiviticins are cytotoxic bacterial metabolites that possess a diazo substituent embedded in a highly oxidized carbocyclic framework (diazofluorene). This review summarizes their isolation, structural elucidation, and biosynthesis, synthetic studies in this area, and chemical biological investigations.

Graphical abstract: The diazofluorene antitumor antibiotics: Structural elucidation, biosynthetic, synthetic, and chemical biological studies
4 items

About this collection

This collection highlights winners of the Natural Product Reports Emerging Investigator Lectureship. This annual lectureship, established in 2010, recognizes an early-stage career scientist who has made a significant contribution to a natural products-related area of the chemical sciences in their early independent career..

The winner of 2018 Emerging Investigator Lectureship is Professor Konrad K. Tiefenbacher (University of Basel, Switzerland).

2018 Winner Profile

Konrad Tiefenbacher received his chemical basic education at the Technical University of Vienna and the University of Texas in Austin. After finishing his diploma thesis in the lab of Prof. Fröhlich, he pursued his interest in total synthesis of biologically active natural products during a Ph.D. in the lab of Prof. Mulzer at the University of Vienna. He then moved to Prof. Rebek’s lab at The Scripps Research Institute in La Jolla to learn about molecular recognition and self-assembly. In December 2011 he started his independent career as a Junior professor (W1-position) at the Technical University Munich. In June 2016 he was appointed to a dual tenure track assistant professorship at the University of Basel and the ETH Zürich.

Winners of the Natural Product Reports Emerging Investigator Lectureship

2013       Rebecca Goss (University of St Andrews, UK)

2014       Emily Balskus (Harvard University, USA)

2015       Seth Herzon (Yale University, USA)

2016       Ryan Shenvi (The Scripps Research Institute, USA)

2017       Katherine S. Ryan (University of British Columbia, Canada)

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