Scaling up for success: from bioactive natural products to new medicines
Discovery and scalable production of natural product drugs require a combination of molecular biology, data science, chemistry and fermentation methods. Here, we describe our drug discovery toolbox and share our perspective on future directions.
Debottlenecking cytochrome P450-dependent metabolic pathways for the biosynthesis of commercial natural products
Exploring metabolic and protein engineering solutions, this article discusses breakthroughs in enhancing cytochrome P450 performance, paving the way for more sustainable and efficient bioprocesses in natural product manufacturing.
Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides
A highlight on the discovery of the antifungal enfumafungin, its biosynthesis, activity profile and mode of action that led to the development program of ibrexafungerp, the first oral antifungal agent approved in more than 20 years.
Chemical case studies from natural products of recent interest in the crop protection industry
Through the lens of chemical case studies, this review examines most recent and selected iconic natural product classes in crop protection.
Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production
Complex regulatory mechanisms govern daptomycin biosynthesis in Streptomyces roseosporus. Ten regulatory genes modulate transcription of daptomycin biosynthetic genes from a single promoter, and translation is coordinated by translational coupling.
About this collection
This collection, guest edited by Eriko Takano and Margherita Sosio, aims to highlight the diverse industrial conceptual approaches, and perspectives, that are laying the way for the modern pharmaceutical industry.